Influenza A virus lures autophagic protein LC3 to budding sites.
نویسنده
چکیده
Autophagy, a cellular degradation pathway, can restrict or assist viral replication. In this issue of Cell Host & Microbe, Beale et al. (2014) report that the influenza virus matrix protein 2 binds to the essential autophagy protein LC3 to presumably transport LC3-conjugated membranes to the cell surface for budding of stable viruses.
منابع مشابه
A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability
Autophagy recycles cellular components and defends cells against intracellular pathogens. While viruses must evade autophagocytic destruction, some viruses can also subvert autophagy for their own benefit. The ability of influenza A virus (IAV) to evade autophagy depends on the Matrix 2 (M2) ion-channel protein. We show that the cytoplasmic tail of IAV M2 interacts directly with the essential a...
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عنوان ژورنال:
- Cell host & microbe
دوره 15 2 شماره
صفحات -
تاریخ انتشار 2014